1. Kirsten Dunst as Hedril
Best known for playing Mary Jane Watson in the Spider-Man films, Dunst appeared in the TNG episode Dark Page when she was just eleven-years-old.
2. Ashley Judd as Ensign Robin Lefler
In her very first on screen credit, Ashely Judd appeared in 2 episodes of Star Trek: The Next Generation (The Game and Darmok) as a love interest for Wesley Crusher. Poor girl.
3. Seth Macfarlane as Ensign Rivers / Engineer
The Family Guy creator made two appearances on Star Trek: Enterprise. Credited as Engineer in The Forgotten, and the following year as Ensign Rivers in Affliction.
4. Mick Fleetwood as Antedian Dignitary
The Fleetwood Mac drummer, and huge Star Trek fan, was totally unrecognisable as the Antedian Dignitary in the TNG episode Manhunt.
5. Iggy Pop as Yelgrun
Another rocker who donned a disguise. Iggy Pop played the Vorta overseer working for the Dominion in the Star Trek: Deep Space Nine episode The Magnificent Ferengi.
6. Sarah Silverman as Rain Robinson
In 1996 Silverman appeared in the two-part Star Trek: Voyager episode Future's End.
7. Dwayne Johnson as The Champion
Back when he liked to be known as The Rock, you could smell what Dwayne Johnson was cooking in the Voyager episode Tsunkatse.
8. Bryan Singer as Kelly the Tactical Officer
The director of this years X-Men: Days of Future Past is a huge Star Trek fan and managed to get himself a brief uncredited cameo in Star Trek: Nemesis.
9. Famke Janssen as Kamala
Sticking with the X-Men, in only her second TV role Famke Janssen appeared in the 1992 TNG episode The Perfect Mate.
10. Teri Hatcher as Chief B. G. Robinson
Not only were Famke Janssen and Teri Hatcher both Bond girls, but they both have an episode of TNG to their names. Hatcher appearing in the 1988 story The Outrageous Okona.
11. Ken Jenkins as Dr. Paul Stubbs
You may well know him as Dr. Bob Kelso from Scrubs, but back in 1989 he played a different Doctor on the TNG episode Evolution.
12. Gregory Itzen as lots of people
He starred as the villainous President Charles Logan, in the TV series 24, but before that actor Gregory Itzen played five different characters in Star Trek! He appeared twice in Deep Space Nine (playing Hain and Ilon Tandro), once on Voyager (as Dr. Dysek) and twice on Enterprise (as Admiral Black and Captain Sopek).
13. Jason Alexander as Kurros
He played George on Seinfeld, and appeared in the Voyager episode Think Tank.
14. Christopher Lloyd as Commander Kruge
Great Scott! Before he invented a time machine in the shape of a Delorean, Christopher Lloyd starred in Star Trek III: The Search For Spock.
15. Tom Morello as Son'a Officer / Crewman Mitchell
Tom Morello, guitarist with Rage Against The Machine, has made two appearances in Star Trek. Firstly in the 1998 movie Insurrection, and later in the Voyager episode Good Shepherd.
16. Christian Slater as Excelsior Communications Officer
Christian Slater somehow managed to get himself a cameo in Star Trek VI: The Undiscovered Country as a night duty officer.
17. Kelsey Grammer as Captain Morgan Bateson
"Hey look, it's Frasier.", something that Kelsey Grammer will never tire of hearing, I'm sure! In 1992 Frasier appeared in the TNG episode as the Captain of the USS Bozeman. There was no sign of his brother, Niles.
18. Bebe Neuwirth as Lanel
"Look, it's Frasier's wife". 'Lilith' starred in the 1991 TNG episode First Contact as a nurse who got it on with Riker.
19. Kirstie Alley as Saavik
Also to be found at Cheers, along with Frasier, was Kirstie Alley. Her first ever starring credit came as Saavik in the 1982 movie Star Trek II: The Wrath Of Khan.
20. Abdullah II King of Jordan as Science Division Officer
OK, so we're not talking Hollywood royalty, rather actual royalty. Back when he was just a Prince, Abdullah bin Al-Hussein had a non-speaking role in the Voyager episode Investigations.
21. Kim Cattrall as Lt. Valeris
Seven years before she landed her most famous role of Samantha in Sex And The City, Kim Cattrall appeared in Star Trek VI: The Undiscovered Country.
22. Kurtwood Smith as lots of people
Kurtwood Smith is another actor who has appeared in multiple roles across various Treks. He was the Federation President in Star Trek VI: The Undiscovered Country, he played Thrax in the Deep Space Nine episode Things Past, and Annorax in the two-part Voyager episode Year Of Hell.
23. James Cromwell as lots of people
One more actor with multiple roles is James Cromwell. Most famous in Trek for his portrayal of Zefram Cochran in the 1996 movie Star Trek: First Contact (a role he reprised in the Enterprise pilot episode Broken Bow), Cromwell had already appeared as Hanok in the Deep Space nine episode Starship Down, and had two different part in TNG. He played Jaglom Shrek in the two-part episode Birthright, and Prime Minister Nayrokin The Hunted.
24. Nikki Cox as Sarjenka
Years before she starred in Las Vegas and an array of cancelled sitcoms, 11 year old Nikki Cox guest starred on the TNG episode Pen Pals.
25. Stephen Hawking as Stephen Hawking
In a classic TNG moment during the episode Descent: Part 1, Data assembled the ultimate Holodeck poker night with the help of Albert Einstein, Sir Isaac Newton and Stephen Hawking. Unfortunately both Einstein and Newton had other 'commitments' that stopped them from partaking themselves, but Hawking made his first acting appearance.
Did you know all of those? And have we missed any?
Let us know in the comments below...
Thanks for all your suggestions of other famous guest stars. I've added some of the best ones below. But before I get to them a big special thanks to 'Uncle Noah' who pointed out that we...
"didn't mention that Patrick Stewart, known for playing Gurney Halleck in "Dune" and more recently for playing Professor Charles Xavier in the X-Men films, was in many episodes of TNG."I'm going to need to find a source for that!!!
26. Jonathan Banks
Mike from Breaking Bad (and the upcoming Better Call Saul) played Shel-la in the 1993 Deep Space Nine episode Battle Lines.
27. Terry O'Quinn
Most famous for playing John Locke in Lost, Terry O'Quinn guest starred as Admiral Eric Pressman in The Next Generation episode The Pegasus.
28. Dean Stockwell
Reuniting with his Quantum Leap co-star, Dean Stockwell joined Scott Bakula for the Enterprise episode Detained.
29. Joan Collins
Some 15 years before Dynasty, Joan Collins appeared as Sister Edith Keeler in the classic Original Series episode The City on the Edge of Forever.
30. Peter Weller
Old RoboCop himself, Peter Weller, was not only in the most recent Trek movie, Star Trek Into Darkness, where he played Admiral Alexander Marcus, but he also appeared in Enterprise back in 2005. At that time he played John Frederick Paxton in the fourth season episodes Terra Prime and Demons.
31. Jim O'Heir
It's Jerry from Parks & Recreation. He had a small cameo as the Jye Husband in the Voyager episode Critical Care
32. Adam Scott
Also currently starring on Parks & Recreation, Adam Scott made one of his very first movie appearances, albeit briefly, in Star Trek: First Contact as the USS Defiant's Conn Officer.
33. John Larroquette
Night Court's John Larroquette played MALTZ, a Klingon warrior in The Search For Spock.
34. Stephen Collins
He's appeared in just about every show you can think of, but one of Stephen Collins' first big roles was that of Willard Decker in Star Trek: The Motion Picture.
35. Michael McKean
Another actor who appears to have been in almost every show that ever existed is Michael McKean. In 1996 he played the Clown in the Voyager episode The Thaw.
Here's another 5 great guest stars you might not know about...
36. Mark Sheppard
It's Crowley, Supernatural's King of Hell. But in 2000 he guest starred on the Voyager episode Child's Play as Leucon.
37. Michelle Forbes
Known for Battlestar Galactica, True Blood, Orphan Black, The Killing, 24, Prison Break....basically you name it and chances are Michelle Forbes has been in it. You may well know that she starred in 8 episodes on TNG as Ro Laren, but you might be unaware that she'd already guest starred on the same series previously - in the 1991 episode Half a Life she played Dara (above).
38. Kevin Peter Hall
Keven Peter Hall is the guy who played the Predator in The Predator and Harry in Harry and the Hendersons. There he is above, barely making it into the shot as he guest stars as Leyor on the 1989 TNG episode The Price.
39. Saul Rubinek
You may well know him as Artie Nelson from Warehouse 13 but back in 1990 he was Kivas Fajo in the TNG episode The Most Toys.
40. Andy Dick
From NewsRadio, Less Than Perfect and The Andy Dick Show it's Andy Dick! In 1998 he portrayed the EMH-Mark II in the Voyager episode Message In A Bottle.
We don't like to split things up if we don't have to, and we promise that we'll never be the type of site that makes you click a new page for every single item (we hate those sites, don't you?), but thanks to all your fantastic suggestions this page is starting to get a bit long. So we've added a second page to continue our round-up of famous people who have guest starred on Star Trek, and because we feel a little guilty about it you won't find any extra advertising present. Is that OK?
Keep the suggestion coming below, and we'll keep updating the list...
You may also like our other Star Trek trivia articles
15 Things You Might Not Know About Star Trek: The Motion Picture
10 Things You Might Not know About Star Trek II: The Wrath Of Khan
10 Things You Might Not know About Star Trek III: The Search For Spock
10 Things You Might Not know About Star Trek IV: The Voyage Home
10 Things You Might Not know About Star Trek V: The Final Frontier
10 Things You Might Not know About Star Trek VI: The Undiscovered Country
10 Things You Might Not know About Star Trek: Generations
10 Things You Might Not know About Star Trek: First Contact
10 Things You Might Not know About Star Trek: Insurrection
10 Things You Might Not know About Star Trek: Nemesis
10 Things You Might Not know About Star Trek (2009)
10 Things You Might Not know About Star Trek Into Darkness
10 Things You Might Not know About Star Trek: TOS
10 Things You Might Not know About Star Trek: The Next Generation
10 Things You Might Not know About Star Trek: Deep Space Nine
20 Things You Might Not know About Star Trek: Voyager
10 Things You Might Not Know About William Shatner
10 Things You Might Not Know About Leonard Nimoy
10 More Things You Might Not Know About Leonard Nimoy